Meet Ms. Harper
Meet Ms. Harper, a 63-year-old retired teacher who hasn't sung in her church choir for over a year. Something that once brought her immense joy has now become a burden that lurks in her mind each and every day. Ms. Harper’s been dealing with a voice that cracks and sounds gravelly (hoarse vocal quality), a cough that pesters her after every meal, and the perpetual, maddening feeling of a lump stuck right… here! (pointing to the area just above the thyroid cartilage or Adam’s apple).
Her primary doctor put her on proton pump inhibitors, but the voice issues and the throat clearing persist. She feels frustrated, defeated, and, worst of all, silenced…
Laryngopharyngeal Reflux (LPR): The Real Culprit
Ms. Harper's problem is likely Laryngopharyngeal Reflux (LPR). It's often confused with simple heartburn, but LPR is acid and pepsin irritating the sensitive tissues of the throat and larynx (voice box).
The good news? Our combined therapeutic strategies—from medications to specialized voice therapy—don't just treat the burn; they can restore the voice and normalize the swallow too.
How Can Something That Starts in the Stomach Affect Your Voice?
Have you ever wondered how reflux can turn into a voice problem? It’s actually more straightforward than it might seem, and it starts with the fact that the laryngeal tissues are not built for the highly acidic, caustic material created by the stomach.
Think about it like this — the stomach is an acid-creating machine. Why? It needs to break down the tough, hard, fibrous food materials that we swallow. This acid is strong. How strong? Let’s put it this way: strong enough to dissolve a razor blade… literally (but please don’t try to eat one and find out).
The stomach is lined with thick mucus and specialized cells that protect it against the acidic environment needed to break down food and process it into the bloodstream.
When reflux occurs, that acid makes its way up to parts of the body that are not as well-equipped for it — like the vocal folds, two bands of tissue that vibrate to create speech. When this happens, it causes tissue damage and inflammation.
Hoarseness (dysphonia) is the most common complaint, affecting 65–95% of patients who suffer from LPR. This statistic illustrates just how frequently vocal problems accompany reflux.
Treating the Root Cause: Targeted Reflux Therapy
We now know that targeted anti-reflux treatment is the key to vocal restoration.
The numbers don’t lie. Treating the underlying acid problem produces measurable vocal change. And studies combining PPIs (Proton Pump Inhibitors) with lifestyle changes didn't just make patients feel better; they significantly improved objective acoustic parameters like jitter, shimmer, and noise-to-harmonic ratio (NHR) in dysphonic patients — metrics that show the vocal folds are physically recovering.
Simply taking a pill isn't always enough. Recovery takes work, no matter what you’re recovering from. Assuming otherwise is like assuming you’ll dunk a basketball just because you bought a pair of Jordans.
When we combine anti-reflux medication with specialized voice therapy, often directed by a speech-language pathologist (SLP), patients report significantly greater and faster reduction in symptoms like hoarseness and chronic cough. Voice therapy reduces vocal hyperfunction and improves vocal hygiene, helping the laryngeal tissue recover more quickly than medication alone.
Every Batman needs a Robin, right?
When Reflux Affects Swallowing
In many cases, LPR symptoms create that maddening "lump" in the throat or make swallowing food feel effortful. LPR frequently impacts the entire swallowing pathway, leading to dysphagia (difficulty swallowing) and globus pharyngeus (the sensation of a lump in the throat).
If you’ve ever felt this, you know it’s not just a feeling — it’s unnerving. Our upper airway is shared real estate for both breathing and swallowing. So when something feels stuck, it triggers a sense of urgency, even if we can still breathe.
What Causes Globus?
The cause and effect can be complex and often multifactorial, but globus is frequently related to GERD and LPR. It’s considered an atypical manifestation of reflux, caused by acid and pepsin reaching the pharynx and larynx, especially near the thyroid notch.
This exposure triggers inflammation in the upper airway, leading to chronic irritation and heightened sensitivity. The globus sensation is often linked to posterior commissure hypertrophy (tissue swelling behind the vocal folds), which improves as inflammation resolves.
In short: the throat becomes hypersensitive, and the brain-larynx feedback loop overreacts to minor irritation — a protective instinct tied to the fear of choking.
Treatment Beyond Standard Acid Suppression
Treatment sometimes requires more than standard acid suppression. Traditional antireflux medications alone can be inconsistent, so management may include multiple complementary approaches:
-
Relaxation and breathing strategies
-
Alginate therapy (like RefluxRaft)
-
Dietary and lifestyle changes
-
Weight management
For patients with persistent symptoms (refractory LPR), we may consider physical reinforcement approaches. One example is using a noninvasive external UES compression device (Reflux Band) to reduce reflux events. Clinical research shows significant symptom reduction when used alongside medication.
Is Surgery Worth It?
In severe or refractory cases, yes — surgery can help. Procedures like Antireflux Surgery (ARS) or Laparoscopic Nissen Fundoplication (LNF) offer rapid and sustained relief, especially when mechanical weakness is the culprit.
For professional voice users who failed high-dose medical management, LNF resolved or nearly resolved symptoms in 90% of cases.
The issues most likely to improve after surgery? Exactly the ones that matter most: hoarseness, heartburn, and swallowing.
Of course, surgery carries risks and isn’t for everyone — it’s best reserved for those whose symptoms deeply impact quality of life.
Bringing Ms. Harper’s Voice Back
The evidence is clear: successful LPR management must be personalized and often combines multiple modalities to treat the whole patient. It’s not about one magic bullet — it’s about acid control, physical protection, and laryngeal retraining working together.
For Ms. Harper, that meant:
-
A customized medication plan with her physician
-
Immediate initiation of voice therapy
-
Focused Laryngeal Recalibration Therapy (LRT) to reduce chronic throat clearing and coughing
-
Vocal hygiene strategies to heal mucosal tissue faster
Within eight weeks, Ms. Harper’s voice quality and globus sensation had improved dramatically. She returned to her church choir — singing clearly again.
We didn’t just restore her vocal folds.
We restored her voice, her confidence, and the resonance in her life.
About the Author
George Barnes, MS, CCC-SLP, BCS-S, is a Board-Certified Specialist in Swallowing and Swallowing Disorders with extensive clinical experience in reflux, dysphagia, and aerodigestive function. Known for his evidence-based, patient-centered approach, George advocates for comprehensive evaluation and targeted care plans that address the full scope of swallowing disorders, especially those that defy easy answers. He’s passionate about educating clinicians and empowering patients to understand the root causes of their symptoms better.
References
Aye, R. W., Watkins, J. R., Farivar, A. S., & Louie, B. E. (2018). [Outcomes of Laparoscopic Hill Repair]. *Surgical Endoscopy, 32*(10), 4111–4115.
Branski, R. C. (2014). [Commentary on Laryngeal Lesions and Reflux]. *Journal of Voice, 28*(2), 241–244.
Duncan, D. R., Larson, K., & Rosen, R. L. (2019). Clinical aspects of thickeners for pediatric gastroesophageal reflux and oropharyngeal dysphagia. *Current Gastroenterology Reports, 21*(7), 30.
Hägg, M., Tibbling, L., & Franzén, T. (2015). Muscle training with an oral IQoroR screen (IQS) improves esophageal dysphagia and reflux symptoms. *World Journal of Gastroenterology, 21*(24), 7558–7562.
Hessler, L. K., Xu, Y., Shada, A. L., Johnson, M. K., Funk, L. M., Greenberg, J. A., & Lidor, A. O. (2022). Antireflux surgery leads to durable improvement in laryngopharyngeal reflux symptoms. *Surgical Endoscopy, 36*(1), 778–786. https://doi.org/10.1007/s00464-020-08279-9
Hopkins, C., Yousaf, U., & Pedersen, M. (2015). Acid reflux treatment for hoarseness. *Cochrane Database of Systematic Reviews*, (4). Article No.: CD005054. https://doi.org/10.1002/14651858.CD005054.pub3
Huestis, M. J., Keefe, K. R., Kahn, C. I., Tracy, L. F., & Levi, J. R. (2020). Alternatives to acid suppression treatment for laryngopharyngeal reflux. *Annals of Otology, Rhinology & Laryngology, 129*(10), 1030–1039. https://doi.org/10.1177/0003489420922870
Hutnik, R., Zlatopolsky, A., Mehraban-Far, S., Alrassi, J., McMillan, N., Amadi, C., Fujita, K., & Mortensen, M. (2020). Laryngopharyngeal reflux: Comparing improvements in reflux symptom index with reflux finding score. *American Journal of Otolaryngology, 41*(6), 102730.
Kim, S. I., Lee, Y. C., Cha, W., Jung, A. R., Jang, J. Y., Choi, J.-S., Lee, D. K., Lee, H. H., Kwon, M. S., Lee, Y. S., & Eun, Y.-G. (2024). Efficacy and safety of fexuprazan in patients with symptoms and signs of laryngopharyngeal reflux disease: a randomized clinical trial. *European Archives of Oto-Rhino-Laryngology, 281*(11), 5873–5883. https://doi.org/10.1007/s00405-024-08877-6
Kosztyła-Hojna, B., Rogowski, M., Duchnowska, E., Zdrojkowski, M., & Łobaczuk-Sitnik, A. (2024). Multidimentional assessment of voice quality in patients with laryngopharyngeal reflux disease. *Otolaryngologia Polska, 78*(1), 20–30. https://doi.org/10.5604/01.3001.0053.7519
Krause, A. J., & Yadlapati, R. (2024). Current evidence based diagnostic and management strategies in patients with LPR. *Aliment Pharmacol Ther, 59*(5), 616–631. https://doi.org/10.1111/apt.17858
Lechien, J. R., Delvaux, V., Huet, K., Finck, C., Khalife, M., Piccaluga, M., Harmegnies, B., & Saussez, S. (2020). Phonetic approaches of laryngopharyngeal reflux disease: a prospective study. *Journal of Voice, 34*(1), 112–120. https://doi.org/10.1016/j.jvoice.2018.08.018
Lechien, J. R., Finck, C., Costa de Araujo, P., Huet, K., Delvaux, V., Piccaluga, M., Harmegnies, B., & Saussez, S. (2017). Voice outcomes of laryngopharyngeal reflux treatment: A systematic review of 1483 patients. *European Archives of Oto-Rhino-Laryngology, 274*(1), 1–23. https://doi.org/10.1007/s00405-016-3984-7
Lechien, J. R., Finck, C., Khalife, M., Huet, K., Delvaux, V., Piccaluga, M., Harmegnies, B., & Saussez, S. (2018). Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease. *Clinical Otolaryngology, 43*(5), 1273–1282. https://doi.org/10.1111/coa.13140
Lechien, J. R., Huet, K., Khalife, M., Fourneau, A.-F., Delvaux, V., Piccaluga, M., Harmegnies, B., & Saussez, S. (2016). Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study. *Journal of Otolaryngology-Head and Neck Surgery, 45*(1), 59.
Lechien, J. R., Huet, K., Khalife, M., Fourneau, A.-F., Delvaux, V., Piccaluga, M., Harmegnies, B., & Saussez, S. (2019). Impact of laryngopharyngeal reflux on subjective and objective voice assessments in patients responding to therapy. *Journal of Voice, 33*(6), 929–939. https://doi.org/10.1016/j.jvoice.2018.05.014
Lechien, J. R., Bobin, F., Muls, V., Horoi, M., Thill, M. P., Rodriguez, A., Saussez, S., Hans, S., & Rodriguez, A. (2022). [Personalized treatment and reflux characteristics in LPR]. *European Archives of Oto-Rhino-Laryngology, 279*(7), 3543–3549.
Lee, J. S., Lee, Y. C., & Eun, Y. G. (2014). Change of QOL in LPR patients. *Journal of Voice, 28*(4), 487–491. https://doi.org/10.1016/j.jvoice.2013.12.015
Li, Z., Tao, L., Zhang, S.-S., Sun, X.-H., Chen, S.-N., & Wu, J. (2021). Modified Xiaochaihu Decoction for gastroesophageal reflux disease: A randomized double-simulation controlled trial. *World Journal of Gastroenterology, 27*(28), 4710–4721. https://doi.org/10.3748/wjg.v27.i28.4710
Liu, J. J., Carr-Locke, D. L., Osterman, M. T., Li, X., Maurer, R., Brooks, D. C., Ashley, S. W., & Saltzman, J. R. (2006). Endoscopic treatment for atypical manifestations of gastroesophageal reflux disease. *American Journal of Gastroenterology*. https://doi.org/10.1111/j.1572-0241.2006.00496.x
Mjönes, A. B., Ledin, T., Grahn, L. T., & Hultcrantz, E. (2005). Hoarseness and misdirected swallowing before and after antireflux surgery. *Acta Otolaryngologica, 125*(1), 82–85.
Mozzanica, F., Robotti, C., Ginocchio, D., Pirola, F., Mengucci, A., Ponzini, I., Piloni, V., Ceriani, S., Alvini, M., Cozza, L., & Ottaviani, F. (2020). [Vocal Tract Discomfort and Dysphonia in Patients]. *Journal of Voice, 34*(2), 280–288.
Park, J.-O., Shim, M.-R., Hwang, Y.-S., Cho, K.-J., Joo, Y.-H., Cho, J.-H., Nam, I.-C., Kim, M.-S., & Sun, D.-I. (2012). Combination of voice therapy and antireflux therapy rapidly recovers voice-related symptoms in laryngopharyngeal reflux patients. *Otolaryngology–Head and Neck Surgery, 146*(1), 92–97. https://doi.org/10.1177/0194599811422014
Pompeu, C. M. R., Sales, T. M. A. L., Nicolau, L. A. D., Matos, A. C. R. d. S., Borsaro, A. A. F., Coutinho, T. A. A., Nogueira, L. F. A., Távora, F. R. F., Souza, M. Â. N. e., Siffrim, D., & Souza, M. H. L. P. d. (2025). Mucosal integrity of the larynx and hypopharynx and the response to proton pump inhibitors in patients with laryngopharyngeal reflux. *European Archives of Oto-Rhino-Laryngology, 282*(4), 2159–2164. https://doi.org/10.1007/s00405-025-09214-1
Sahin, M., Vardar, R., Ersin, S., Engin, E. Z., Bor, S., Kilic, A., Sayin, B., Kirazli, T., Canda, T., Memic, I. F., & Sahin, M. (2015). The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters. *European Archives of Oto-Rhino-Laryngology, 272*(11), 3375–3383.
Song, S., Zhang, Y., Zhang, J., Jiang, Y., & Gong, A. (2024). Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease. *Medicine (Baltimore), 103*(24), e38045.
Walsh, E., Weissbrod, P., Greytak, M., Yadlapati, R., Krause, A. J., King, A. M., & Taft, T. (2024). [Therapeutic strategies for chronic laryngeal symptoms]. *American Journal of Gastroenterology, 119*(11), 2198–2205.
Weber, B., Portnoy, J. E., Castellanos, A., Hawkshaw, M. J., Lurie, D., Katz, P. O., & Sataloff, R. T. (2014). Efficacy of anti-reflux surgery on refractory laryngopharyngeal reflux disease in professional voice users: A pilot study. *Journal of Voice, 28*(4), 492–500. https://doi.org/10.1016/j.jvoice.2013.12.009
Willems-Bloemer, L. H., Vreeburg, G. C. M., & Brummer, R.-J. M. (2000). Treatment of reflux-related and non-reflux-related dysphonia with profound gastric acid inhibition. *Folia Phoniatrica et Logopaedica, 52*, 289–294.
Yadlapati, R., Pandolfino, J. E., Greytak, M., Cahoon, J., Clarke, M., Clary, M., Fink, D., Menard-Katcher, P., Vahabzadeh-Hagh, A. M., Weissbrod, P., Gupta, S., Kaizer, A., & Wani, S. (2022). Upper esophageal sphincter compression device as an adjunct to proton pump inhibition for laryngopharyngeal reflux. *Digestive Diseases and Sciences, 67*(7), 3045–3054. https://doi.org/10.1007/s10620-021-07172-2
Zehetner, J., Harsányi, L., Kincses, Z., Veselinović, M., & Altorjay, Á. (2025). [Novel RefluxStop procedure and improvements on standard-of-care anti-reflux surgery]. *Surgical Endoscopy, 39*(9), 6163–6179.
Zhang, B., Hu, Y., Liu, W., Zhu, X., Shuai, X., Li, F., Xu, M., Lu, J., Huang, Y., Zhang, Y., Li, Z., Zhang, L., Chen, J. D. Z., & Xie, W.-F. (2021). Ameliorating effects and autonomic mechanisms of transcutaneous electrical acustimulation in patients with gastroesophageal reflux disease. *American Journal of Gastroenterology, 116*(7), 1495–1505.
Disclaimer: This article is for educational purposes only and is not intended to diagnose or treat any medical condition. Always consult your healthcare provider before making changes to your treatment plan.